Clinical and Pathologic Changes in a Guinea Pig Aerosol Challenge Model of Acute Q Fever
نویسندگان
چکیده
منابع مشابه
Clinical and pathologic changes in a guinea pig aerosol challenge model of acute Q fever.
Acute Q fever is a zoonotic disease caused by the obligate intracellular bacterium Coxiella burnetii and can manifest as a flu-like illness, pneumonia, or hepatitis. A need exists in Q fever research for animal models mimicking both the typical route of infection (inhalation) and the clinical illness seen in human cases of Q fever. A guinea pig aerosol challenge model was developed using C. bur...
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As assessed by both standard histological staining and immunochemistry, intraperitoneal inoculation of C. burnetii in guinea pigs led to pathologic changes mainly in the liver, whereas intranasal inoculation led to pathologic changes mainly in the lungs. Myocarditis and positive blood cultures were observed only in those animals which received the highest inoculum. We therefore conclude that bo...
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Background and purpose: Q fever is a worldwide zoonosis which is an endemic in many regions. Its diagnosis is usually missed especially in human. This research aimed at investigating acute Q fever among suspected patients in northern Iran. Materials and methods: This cross-sectional study was conducted in 56 suspected cases of Q fever selected from 476 febrile patients admitted in Qaemshahr R...
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Q fever is a zoonotic disease of worldwide significance caused by the obligate intracellular bacterium Coxiella burnetii. Humans with Q fever may experience an acute flu-like illness and pneumonia and/or chronic hepatitis or endocarditis. Various markers demonstrate significant phylogenetic separation between and clustering among isolates from acute and chronic human disease. The clinical and p...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2006
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.00763-06